Dynamic expression of 11 miRNAs in 83 consecutive primary and corresponding recurrent glioblastoma: correlation to treatment, time to recurrence, overall survival and MGMT methylation status

Radiology and Oncology

Emanuela Bostjancic^2¹  Bostjan Matos^1²  Alenka Matjasic^2³ 

[1] Department of Molecular Genetics, Ljubljana, Slovenia^2;Department of Neurosurgery, Ljubljana, Slovenia^1;Institute of Pathology, Faculty of Medicine, Ljubljana, Slovenia^3

关键词: glioblastoma;    recurrent;    radiotherapy;    chemotherapy;    miRNA;    expression;   

DOI  :  10.2478/raon-2018-0043

学科分类：肿瘤学

来源: Onkoloski Institut Ljubljana / Institute of Oncology Ljubljana

【 摘 要 】

BackgroundGlioblastoma (GBM) is the most common and the most malignant glioma subtype. Among numerous genetic alterations, miRNAs contribute to pathogenesis of GBM and it is suggested that also to GBM recurrence and resistance to therapy. Based on publications, we have selected 11 miRNAs and analyzed their expression in GBM. We hypothesized that selected miRNAs are differentially expressed and involved in primary as well as in recurrent GBM, that show significant expressional differences when different treatment options are in question, and that are related to certain patients and tumor characteristics.

【 授权许可】

Unknown