Increased MFG‐E8 at neuromuscular junctions is an exacerbating factor for sarcopenia‐associated denervation

Aging Cell

Mitsuhiro Morita¹  Nobuo Kanazawa²  Kunihiro Tsuchida³  Heying Zhou⁴  Yuki Yoshimoto⁴  Akiyoshi Uezumi⁴  Madoka Ikemoto‐Uezumi⁴  Tamaki Kurosawa⁵  Tatsu Nakazawa⁶  Masashi Toyoda⁷ 

[1] Department of Orthopaedic Surgery, Fujita Health University, Toyoake, Japan;Department of Surgery, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan;Division for Therapies against Intractable Diseases, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Japan;Muscle Aging and Regenerative Medicine, Tokyo Metropolitan Institute of Gerontology (TMIG), Tokyo, Japan;Muscle Aging and Regenerative Medicine, Tokyo Metropolitan Institute of Gerontology (TMIG), Tokyo, Japan;Laboratory of Veterinary Pharmacology, Department of Veterinary Medical Sciences, Graduate School of Agriculture and Life Sciences, Tokyo University, Tokyo, Japan;Seibo Hospital, Tokyo, Japan;Vascular Medicine, TMIG, Tokyo, Japan;

关键词: aging;    denervation;    MFG‐E8;    neuromuscular junction;    sarcopenia;    skeletal muscle;   

DOI  :  10.1111/acel.13536

来源: Wiley

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