Loss of lamin‐B1 and defective nuclear morphology are hallmarks of astrocyte senescence in vitro and in the aging human hippocampus

Aging Cell

Ricardo Nitrini¹  Lea T. Grinberg²  Renata E. P. Leite³  Claudia K. Suemoto³  Wilson Jacob‐Filho³  Elly M. Hol⁴  Jinte Middeldorp⁵  Ana Paula Bergamo Araujo⁶  Gabriele Vargas⁶  Laís da Silva Neves⁶  Isadora Matias⁶  Isabella Vivarini Damico⁶  Luan Pereira Diniz⁶  Flávia Carvalho Alcantara Gomes⁶ 

[1] Brazilian Aging Brain Study Group, University of São Paulo Medical School, São Paulo, Brazil;Brazilian Aging Brain Study Group, University of São Paulo Medical School, São Paulo, Brazil;Department of Neurology, Memory and Aging Center, University of California San Francisco, San Francisco, California, USA;Department of Pathology, University of California San Francisco, San Francisco, California, USA;Brazilian Aging Brain Study Group, University of São Paulo Medical School, São Paulo, Brazil;Division of Geriatrics, University of São Paulo Medical School, São Paulo, Brazil;Department of Translational Neuroscience, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands;Department of Translational Neuroscience, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands;Department of Immunobiology, Biomedical Primate Research Center, Rijswijk, The Netherlands;Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil;

关键词: aging;    astrocyte;    human and mouse hippocampus;    lamin‐B1;    senescence;    synapse;   

DOI  :  10.1111/acel.13521

来源: Wiley

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