Necroptosis contributes to chronic inflammation and fibrosis in aging liver

Aging Cell

Ramasamy Selvarani¹  Evan H. Nicklas¹  Nidheesh Thadathil¹  Dawei Wang¹  Benjamin F. Miller²  Sabira Mohammed³  Sathyaseelan S. Deepa⁴  Arlan Richardson⁵ 

[1] Department of Biochemistry and Molecular Biology, Oklahoma City, OK, USA;Department of Biochemistry and Molecular Biology, Oklahoma City, OK, USA;Oklahoma Center for Geroscience & Brain Aging, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA;Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA;Stephenson Cancer Center, Oklahoma City, OK, USA;Stephenson Cancer Center, Oklahoma City, OK, USA;Department of Biochemistry and Molecular Biology, Oklahoma City, OK, USA;Oklahoma Center for Geroscience & Brain Aging, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA;Stephenson Cancer Center, Oklahoma City, OK, USA;Department of Biochemistry and Molecular Biology, Oklahoma City, OK, USA;Oklahoma Center for Geroscience & Brain Aging, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA;Oklahoma City VA medical Center, Oklahoma City, OK, USA;

关键词: aging;    fibrosis;    inflammation;    liver;    necroptosis;    necrostatin‐1s;   

DOI  :  10.1111/acel.13512

来源: Wiley

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