Developing a New qFIBS Model Assessing Histological Features in Pediatric Patients With Non-alcoholic Steatohepatitis

Frontiers in Medicine

article

Feng Liu¹  Lai Wei²  Wei Qiang Leow³  Shu-Hong Liu⁵  Ya-Yun Ren⁶  Xiao-Xiao Wang¹  Xiao-He Li¹  Hui-Ying Rao¹  Rui Huang¹  Nan Wu¹  Aileen Wee⁷  Jing-Min Zhao⁵ 

[1] Peking University People's Hospital, Peking University Hepatology Institute, Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases, Beijing International Cooperation Base for Science and Technology on NAFLD Diagnosis;Hepatopancreatobiliary Center, Beijing Tsinghua Changgung Hospital, Tsinghua University;Department of Anatomical Pathology, Singapore General Hospital;Duke-NUS Medical School;Department of Pathology and Hepatology, The Fifth Medical Center of PLA General Hospital;HistoIndex Pte Ltd.;Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, National University Hospital

关键词: automated quantitative evaluation;    fibrosis;    inflammation;    ballooning;    steatosis;    liver;    pediatric NASH;   

DOI  :  10.3389/fmed.2022.925357

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Background The evolution of pediatric non-alcoholic fatty liver disease (NAFLD) to non-alcoholic steatohepatitis (NASH) is associated with unique histological features. Pathological evaluation of liver specimen is often hindered by observer variability and diagnostic consensus is not always attainable. We investigated whether the qFIBS technique derived from adult NASH could be applied to pediatric NASH. Materials and Methods 102 pediatric patients ( 0.85 (0.85–0.95)] and ability to distinguish different stages of fibrosis. qFIBS showed weak correlation with ballooning ( r = 0.38, P = 0.028) and inflammation ( r = 0.46, P = 0.005); however, it could distinguish different grades of ballooning (AUROCs 0.73, sensitivity 0.36, and specificity 0.92) and inflammation (AUROCs 0.77, sensitivity 0.83, and specificity 0.53). Conclusion It was demonstrated that when qFIBS derived from adult NASH was performed on pediatric NASH, it could best distinguish the various histological grades of steatosis and fibrosis.

【 授权许可】

CC BY