S1PR3 is essential for phosphorylated fingolimod to protect astrocytes against oxygen‐glucose deprivation‐induced neuroinflammation via inhibiting TLR2/4‐NFκB signalling

Journal of Cellular and Molecular Medicine

Jun Lu¹  Jin Wu²  Zheng‐Zhen Chen³  Ling Zhang³  Ruo‐Bing Guo³  Juan Ji³  Ji‐Ye Huang³  Xiu‐Lan Sun³  Lu‐Lu Cao³  Yin‐Feng Dong⁴ 

[1]College of Health Sciences, Jiangsu Normal University, Xuzhou, Jiangsu, China

[2]Department of Internal Neurology, the Second Affiliated Hospital, Nanjing, Jiangsu, China

[3]Neuroprotective Drug Discovery Key Laboratory of Nanjing Medical University, Department of Pharmacology, Nanjing Medical University, Nanjing, Jiangsu, China

[4]Neuroprotective Drug Discovery Key Laboratory of Nanjing Medical University, Department of Pharmacology, Nanjing Medical University, Nanjing, Jiangsu, China

[5]School of Nursing, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China

关键词: astrocyte;    fingolimod;    neuroinflammation;    sphingosine‐1‐phosphate receptor 3;   

DOI  :  10.1111/jcmm.13596

来源: Wiley

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