Selective oxidative stress induces dual damage to telomeres and mitochondria in human T cells

Aging Cell

Dechao Cao¹  Xindi Dang¹  Lam Ngoc Thao Nguyen¹  Sushant Khanal¹  Shunbin Ning¹  Mohamed El Gazzar¹  Lam Nhat Nguyen¹  Juan Zhao¹  Zeyuan Lu¹  Ling Wang¹  Jinyu Zhang¹  Madison Schank¹  Xiao Y. Wu¹  Zhi Q. Yao²  Jonathan P. Moorman² 

[1]Center of Excellence in Inflammation, Infectious Disease and Immunity, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA

[2]Division of Infectious, Inflammatory and Immunologic Diseases, Department of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA

[3]Center of Excellence in Inflammation, Infectious Disease and Immunity, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA

[4]Division of Infectious, Inflammatory and Immunologic Diseases, Department of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA

[5]Hepatitis (HCV/HBV/HIV) Program, Department of Veterans Affairs, James H. Quillen VA Medical Center, Johnson City, Tennessee, USA

关键词: DNA damage and repair;    mitochondria;    oxidative stress;    T cell senescence;    telomeres;   

DOI  :  10.1111/acel.13513

来源: Wiley

【 授权许可】

CC BY