α‐synuclein suppresses microglial autophagy and promotes neurodegeneration in a mouse model of Parkinson’s disease

Aging Cell

Ya‐Ping Yang¹  Chun‐Feng Liu²  Xiao‐Ou Hou²  Hai‐Yue Tu²  Li‐Fang Hu²  Zheng‐Hong Qin³  Yi Fan⁴  Chong‐Shuang Pei⁵  Ya‐Ting Ma⁵  Xiao‐Jun Zhang⁵  Bao‐Shi Yuan⁵ 

[1] Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China;Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China;Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou, Jiangsu, China;Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu, China;Department of Pharmacology, Nanjing Medical University, Nanjing, Jiangsu, China;Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou, Jiangsu, China;

关键词: autophagy;    microglia;    neuroinflammation;    Parkinson's disease;    α‐synuclein;   

DOI  :  10.1111/acel.13522

来源: Wiley

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