Spermidine promotes nucleus pulposus autophagy as a protective mechanism against apoptosis and ameliorates disc degeneration

Journal of Cellular and Molecular Medicine

Sinan Khor¹  Jiawei Li²  Qingqing Wang²  Zili He²  Yu Chen²  Jian Chen²  Xiangyang Wang²  Jian Xiao³  Zengming Zheng³  Hongyu Zhang⁴  Gong Fanghua⁴  Zhou‐Guang Wang⁴  Ke Xu⁵ 

[1] Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA;Department of Orthopaedic Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China;Department of Orthopaedic Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China;School of Pharmaceutical Sciences, Key Laboratory of Biotechnology and Pharmaceutical Engineering, Wenzhou Medical University, Wenzhou, China;School of Pharmaceutical Sciences, Key Laboratory of Biotechnology and Pharmaceutical Engineering, Wenzhou Medical University, Wenzhou, China;The Institute of Life Sciences, Wenzhou University, Wenzhou, China;

关键词: apoptosis;    autophagy;    intervertebral disc degeneration;    oxidative stress;    spermidine;   

DOI  :  10.1111/jcmm.13586

来源: Wiley

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