γ‐Secretase modulators show selectivity for γ‐secretase–mediated amyloid precursor protein intramembrane processing

Journal of Cellular and Molecular Medicine

ShaoBo Jin¹  Hlin Kvartsberg²  Karolina Minta²  Kaj Blennow²  Gunnar Brinkmalm²  Erik Portelius²  Henrik Zetterberg³  Daniel V. Oliveira⁴  Johanna Wanngren⁴  Pia Larssen⁴  Gunnar Nordvall⁵  Johan Lundkvist⁶  Dan Wu⁷  Tobias A. Weber⁸  Bengt Winblad⁹  Helena Karlström⁹ 

[1] Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden;Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden;Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden;Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden;Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden;Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK;UK Dementia Research Institute at UCL, London, UK;Division of Neurogeriatrics, Department of Neurobiology, Care Science and Society, Karolinska Institutet, Stockholm, Sweden;Division of Neurogeriatrics, Department of Neurobiology, Care Science and Society, Karolinska Institutet, Stockholm, Sweden;Alzecure Pharma, Huddinge, Sweden;Division of Neurogeriatrics, Department of Neurobiology, Care Science and Society, Karolinska Institutet, Stockholm, Sweden;Alzecure Pharma, Huddinge, Sweden;Sinfonia Biotherapeutics AB, Huddinge, Sweden;Division of Neurogeriatrics, Department of Neurobiology, Care Science and Society, Karolinska Institutet, Stockholm, Sweden;Department of Obstetrics and Gynecology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China;Division of Neurogeriatrics, Department of Neurobiology, Care Science and Society, Karolinska Institutet, Stockholm, Sweden;Medical Scientific Affairs, Aesculap AG, Tuttlingen, Germany;Division of Neurogeriatrics, Department of Neurobiology, Care Science and Society, Karolinska Institutet, Stockholm, Sweden;Theme Aging, Geriatric Clinic, Karolinska University Hospital, Huddinge, Sweden;

关键词: beta‐amyloid;    gamma‐secretase modulators;    presenilin;    substrates;   

DOI  :  10.1111/jcmm.17146

来源: Wiley

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