Depletion of m6A reader protein YTHDC1 induces dilated cardiomyopathy by abnormal splicing of Titin

Journal of Cellular and Molecular Medicine

Kejing Chen¹  Siyun Gao¹  Liudan Jiang¹  Lei Chen¹  Shengqi Zhang¹  Liang Xu²  Dandan Liang²  Dan Shi²  Yi‐Han Chen³  Yi Liu³  Jian Yang³  Honghui Ma⁴  Hao Chen⁵  Yanjiao Ruan⁵  Xueying Gu⁶  Bin Shen⁶  Hongyu Chen⁶  Haifeng Sun⁶ 

[1] Department of Cardiology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China;Key Laboratory of Arrhythmias of the Ministry of Education of China, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China;Department of Cardiology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China;Key Laboratory of Arrhythmias of the Ministry of Education of China, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China;Institute of Medical Genetics, Tongji University, Shanghai, China;Department of Cardiology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China;Key Laboratory of Arrhythmias of the Ministry of Education of China, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China;Institute of Medical Genetics, Tongji University, Shanghai, China;Department of Pathology and Pathophysiology, Tongji University School of Medicine, Shanghai, China;Department of Cardiology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China;Key Laboratory of Arrhythmias of the Ministry of Education of China, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China;Institute of Medical Genetics, Tongji University, Shanghai, China;Department of Pathology and Pathophysiology, Tongji University School of Medicine, Shanghai, China;Research Units of Origin and Regulation of Heart Rhythm, Chinese Academy of Medical Sciences, Shanghai, China;School of Medicine, Southern University of Science and Technology, Shenzhen, China;State Key Laboratory of Reproductive Medicine, Center for Global Health, Gusu School, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Hospital, Nanjing Medical University, Nanjing, China;

关键词: dilated cardiomyopathy;    epitranscriptomics;    heart failure;    RNA modification;    YTHDC1;   

DOI  :  10.1111/jcmm.16955

来源: Wiley

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