Research progress on N 6 -adenosylate methylation RNA modification in heart failure remodeling

Journal of Translational Internal Medicine

article

Yiqing Yang¹  Mbikyo B Muisha¹  Junzhe Zhang¹  Yingxian Sun¹  Zhao Li¹ 

[1] Department of Cardiology, the First Hospital of China Medical University, Shenyang 110001, Liaoning Province

关键词: RNA modification;    m6A RNA methylation;    cardiac remodeling;    cardiac hypertrophy;    heart failure;   

DOI  :  10.2478/jtim-2022-0025

来源: Walter de Gruyter GmbH

【 摘 要 】

Cardiovascular disease (CVD) is the major cause of disability-adjusted life years (DALY) and death globally. The most common internal modification of mRNA is N6-adenosylate methylation (m6A). Recently, a growing number of studies have been devoted to researching cardiac remodeling mechanisms, especially m6A RNA methylation, revealing a connection between m6A and cardiovascular diseases. This review summarized the current understanding regarding m6A and elucidated the dynamic modifications of writers, erasers, and readers. Furthermore, we highlighted m6A RNA methylation related to cardiac remodeling and summarized its potential mechanisms. Finally, we discussed the potential of m6A RNA methylation in the treatment of cardiac remodeling.

【 授权许可】

Unknown