Novel small molecule inhibition of IKK/NF‐κB activation reduces markers of senescence and improves healthspan in mouse models of aging

Aging Cell

Johnny Huard¹  Xiaodong Mu²  Sara J. McGowan³  Matthew J. Yousefzadeh³  Lei Zhang³  Laura J. Niedernhofer³  Ryan D. O'Kelly³  Luise Angelini³  Paul D. Robbins³  Yousin Suh⁴  Theodore M. Kamenecka⁵  Jing Zhao⁵  Ayumi Sakamoto⁶  Zaira Aversa⁶  Nathan K. LeBrasseur⁶ 

[1] Center for Regenerative Sports Medicine, Steadman Philippon Research Institute, Vail, Colorado, USA;Center for Regenerative Sports Medicine, Steadman Philippon Research Institute, Vail, Colorado, USA;Shandong First Medical University (Shandong Academy of Medical Sciences), Jinan, China;Department of Biochemistry, Molecular Biology and Biophysics, Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, Minnesota, USA;Department of Genetics and Development, Columbia University, New York, New York, USA;Department of Molecular Medicine, Scripps Research, Jupiter, Florida, USA;Department of Physical Medicine and Rehabilitation and Robert and Arlene Kogod Center on Aging, Rochester, Minnesota, USA;

关键词: aging;    NEMO;    NF‐κB;    senescence;    SR12343;   

DOI  :  10.1111/acel.13486

来源: Wiley

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CC BY