Lanthanum Chloride Sensitizes Cisplatin Resistance of Ovarian Cancer Cells via PI3K/Akt Pathway

Frontiers in Medicine

Shanyu Fang¹  Xinping Chen¹  Fujun Liu¹  Fen Wang¹  Ping Zhang² 

[1] Department of Obstetrics and Gynecology, The First Affiliated Hospital of Nanchang University, Nanchang, China;Department of Otorhinolaryngology Head and Neck Surgery, Jiujiang University Clinical Medical College, Jiujiang University Hospital, Jiujiang, China;

关键词: lanthanum chloride;    cisplatin resistance;    ovarian cancer;    PI3K;    Akt;   

DOI  :  10.3389/fmed.2021.776876

来源: Frontiers

【 摘 要 】

Our previous study manifested that lanthanum chloride (LaCl3) can enhance the anticancer ability of cisplatin (DDP) in ovarian cancer cells. Here, ovarian cancer cells SKOV3 and SKOV3/DDP were subjected to DDP and LaCl3. Cell viability, apoptosis, DNA repair, and PI3K/Akt pathway were detected. LaCl3 induced more cell death and apoptosis caused by DDP in two cell lines, accompanied by upregulation of Bax and Cleaved caspase 3 proteins, and downregulation of Bcl-2 protein. LaCl3 also could decrease RAD51 protein by inactivation of the PI3K/Akt pathway. These data indicated that LaCl3 could be a potential drug to modulate DDP resistance by inactivating of PI3K/Akt pathway and attenuating DNA repair in ovarian cancer.

【 授权许可】

CC BY