Recent Progress in Cardiovascular Research Involving Single-Cell Omics Approaches

Frontiers in Cardiovascular Medicine

Zhehao Dai¹  Seitaro Nomura² 

[1] Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan;null;

关键词: single-cell omics;    cardiovascular research;    heart development;    cardiac homeostasis;    myocardial infarction;    heart failure;   

DOI  :  10.3389/fcvm.2021.783398

来源: Frontiers

【 摘 要 】

Cardiovascular diseases are among the leading causes of morbidity and mortality worldwide. Although the spectrum of the heart from development to disease has long been studied, it remains largely enigmatic. The emergence of single-cell omics technologies has provided a powerful toolbox for defining cell heterogeneity, unraveling previously unknown pathways, and revealing intercellular communications, thereby boosting biomedical research and obtaining numerous novel findings over the last 7 years. Not only cell atlases of normal and developing hearts that provided substantial research resources, but also some important findings regarding cell-type-specific disease gene program, could never have been established without single-cell omics technologies. Herein, we briefly describe the latest technological advances in single-cell omics and summarize the major findings achieved by such approaches, with a focus on development and homeostasis of the heart, myocardial infarction, and heart failure.

【 授权许可】

CC BY