Adverse childhood experiences and resilience among adult women: A population-based study

eLife

Arna Hauksdóttir¹  Harpa Rúnarsdóttir¹  Jóhanna Jakobsdóttir¹  Thor Aspelund¹  Gunnar Tómasson¹  Edda Bjork Thordardottir¹  Hilda Björk Daníelsdóttir²  Unnur Anna Valdimarsdóttir³  Thorhildur Halldorsdottir⁴  Katja Fall⁵  Qian Yang⁶  Beatrice Kennedy⁷  Karmel W Choi⁸  Fang Fang⁹  Donghao Lu^1,10  Huan Song^1,11 

[1] Centre of Public Health Sciences, Faculty of Medicine, University of Iceland, Reykjavík, Iceland;Centre of Public Health Sciences, Faculty of Medicine, University of Iceland, Reykjavík, Iceland;Department of Medical Epidemiology & Biostatistics, Karolinska Institutet, Stockholm, Sweden;Centre of Public Health Sciences, Faculty of Medicine, University of Iceland, Reykjavík, Iceland;Department of Medical Epidemiology & Biostatistics, Karolinska Institutet, Stockholm, Sweden;Harvard T.H. Chan School of Public Health, Boston, United States;Centre of Public Health Sciences, Faculty of Medicine, University of Iceland, Reykjavík, Iceland;Department of Psychology, Reykjavík University, Reykjavik, Iceland;Clinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University, Örebro, Sweden;Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden;Department of Medical Epidemiology & Biostatistics, Karolinska Institutet, Stockholm, Sweden;Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden;Department of Psychiatry, Massachusetts General Hospital, Boston, United States;Harvard T.H. Chan School of Public Health, Boston, United States;Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden;Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden;Harvard T.H. Chan School of Public Health, Boston, United States;West China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, China;

关键词: SAGA;    adverse childhood experiences;    child maltreatment;    resilience;    coping ability;    women's health;    Human;   

DOI  :  10.7554/eLife.71770

来源: eLife Sciences Publications, Ltd

【 摘 要 】

Background:Adverse childhood experiences (ACEs) have consistently been associated with elevated risk of multiple adverse health outcomes, yet their contribution to coping ability and psychiatric resilience in adulthood is unclear.Methods:Cross-sectional data were derived from the ongoing Stress-And-Gene-Analysis cohort, representing 30% of the Icelandic nationwide female population, 18–69 years. Participants in the current study were 26,198 women with data on 13 ACEs measured with the ACE-International Questionnaire. Self-reported coping ability was measured with the Connor-Davidson Resilience Scale and psychiatric resilience was operationalized as absence of psychiatric morbidity. Generalized linear regression assuming normal or Poisson distribution were used to assess the associations of ACEs with coping ability and psychiatric resilience controlling for multiple confounders.Results:Number of ACEs was inversely associated with adult resilience in a dose-dependent manner; every 1SD unit increase in ACE scores was associated with both lower levels of coping ability (β = −0.14; 95% CI-0.15,–0.13) and lower psychiatric resilience (β = −0.28; 95% CI-0.29,–0.27) in adulthood. Compared to women with 0 ACEs, women with ≥5 ACEs had 36% lower prevalence of high coping ability (PR = 0.64, 95% CI 0.59,0.70) and 58% lower prevalence of high psychiatric resilience (PR = 0.42; 95% CI 0.39,0.45). Specific ACEs including emotional neglect, bullying, sexual abuse and mental illness of household member were consistently associated with reduced adult resilience. We observed only slightly attenuated associations after controlling for adult socioeconomic factors and social support in adulthood.Conclusions:Cumulative ACE exposure is associated with lower adult resilience among women, independent of adult socioeconomic factors and social support, indicating that adult resilience may be largely determined in childhood.Funding:This work was supported by the European Research Council (Consolidator grant; UAV, grant number 726413), and the Icelandic Center for Research (Grant of excellence; UAV, grant number 163362-051). HBD was supported by a doctoral grant from the University of Iceland Research Fund.

【 授权许可】

CC BY