A green approach to dual-drug nanoformulations with targeting and synergistic effects for cancer therapy

Drug Delivery

Yuan Jiang¹  Shichao Wu¹  Yang Li¹  Xiangrui Yang¹  Yue Lu¹  Zhenqing Hou²  Zhongxiong Fan³ 

[1] Research Institute for Biomimetics and Soft Matter, College of Materials, Xiamen University, Xiamen, China an;Research Institute for Biomimetics and Soft Matter, College of Materials, Xiamen University, Xiamen, China an;The Department of Physics, Changji University, Changji, Chin;The Department of Physics, Changji University, Changji, Chin;

关键词: Dual-drug;    green;    targeting;    anticancer;    nanoformulation;   

DOI  :  10.1080/10717544.2016.1228716

来源: Taylor & Francis

【 摘 要 】

Exploration of efficient dual-drug nanohybrids, particularly those with high drug loading, specific targeting property, and long-termed stability, is of highly importance in cancer therapy. A pH-driven coprecipitation was performed in the aqueous phase to obtain a dual-drug nanoformulation, composed of 10-hydroxycamptothecine (HCPT) nanoneedles integrated with an exterior thin layer of the methotrexate (MTX)–chitosan conjugate. The high stability of nanohybrids in water and the targeting property provided by the MTX ingredient function synergistically to the prolonged and sustained drug release property in tumor tissues and the increased cellular uptake. The cytotoxicity test illustrates that dual-drug nanoneedles possess the remarkable killing ability to HeLa cells with the combination index at 0.33 ± 0.07. After cellular internalization, the release of both drug ingredients results in an excellent anticancer activity in vivo with the minimized adverse side effects. Design of a green approach to the carrier-free, dual-drug nanoformulations enables to develop emerging drug delivery systems for cancer diagnosis and treatment.

【 授权许可】

CC BY