pH-Responsive carriers for oral drug delivery: challenges and opportunities of current platforms

Drug Delivery

WenDong Yao¹  JianQing Gao²  XiaoYang Lu³  YueFeng Rao³  Lin Liu⁴ 

[1] College of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, PR Chin;Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, PR China, an;The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, PR China;The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, PR China;Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, PR China, an;

关键词: pH-Responsive;    oral delivery;    controlled release;    bioavailability;    drug delivery;   

DOI  :  10.1080/10717544.2017.1279238

来源: Taylor & Francis

【 摘 要 】

Oral administration is a desirable alternative of parenteral administration due to the convenience and increased compliance to patients, especially for chronic diseases that require frequent administration. The oral drug delivery is a dynamic research field despite the numerous challenges limiting their effective delivery, such as enzyme degradation, hydrolysis and low permeability of intestinal epithelium in the gastrointestinal (GI) tract. pH-Responsive carriers offer excellent potential as oral therapeutic systems due to enhancing the stability of drug delivery in stomach and achieving controlled release in intestines. This review provides a wide perspective on current status of pH-responsive oral drug delivery systems prepared mainly with organic polymers or inorganic materials, including the strategies used to overcome GI barriers, the challenges in their development and future prospects, with focus on technology trends to improve the bioavailability of orally delivered drugs, the mechanisms of drug release from pH-responsive oral formulations, and their application for drug delivery, such as protein and peptide therapeutics, vaccination, inflammatory bowel disease (IBD) and bacterial infections.

【 授权许可】

CC BY