Application and Characterization of Gum from Bombax buonopozense Calyxes as an Excipient in Tablet Formulation

Pharmaceutics

Ndidi C. Ngwuluka¹  Jehu Kyari¹  John Taplong¹ 

[1] Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, University of Jos, Jos, 930001, Nigeria;

关键词: tablets;    tablet manufacture;    natural gums;    Bombax buonopozense;    drug delivery;    zero order;    controlled release;    dosage forms;    oral delivery;   

DOI  :  10.3390/pharmaceutics4030354

来源: mdpi

【 摘 要 】

This study was undertaken to explore gum from Bombax buonopozense calyxes as a binding agent in formulation of immediate release dosage forms using wet granulation method. The granules were characterized to assess the flow and compression properties and when compressed, non-compendial and compendial tests were undertaken to assess the tablet properties for tablets prepared with bombax gum in comparison with those prepared with tragacanth and acacia gums. Granules prepared with bombax exhibited good flow and compressible properties with angle of repose 28.60°, Carr’s compressibility of 21.30% and Hausner’s quotient of 1.27. The tablets were hard, but did not disintegrate after one hour. Furthermore, only 52.5% of paracetamol was released after one hour. The drug release profile followed zero order kinetics. Tablets prepared with bombax gum have the potential to deliver drugs in a controlled manner over a prolonged period at a constant rate.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.