Neonatal abstinence syndrome is a potential cause of low TREC copy number

Allergy, Asthma & Clinical Immunology

Ling Ling¹  Adil Adatia²  Lauren Brick³  Rae Brager³  Pranesh Chakraborty⁴ 

[1] Department of Medicine, University of Alberta, Edmonton, AB, Canada;Division of Clinical Immunology and Allergy, Department of Medicine, McMaster University, Hamilton, ON, Canada;Division of Rheumatology, Immunology, and Allergy, Department of Pediatrics, McMaster Children’s Hospital, McMaster University, Hamilton, ON, Canada;Newborn Screening Ontario, Children’s Hospital of Eastern Ontario, Ottawa, ON, Canada;Department of Pediatrics, Children’s Hospital of Eastern Ontario, Ottawa, ON, Canada;

关键词: SCID;    Primary immunodeficiency;    TRECs;    Opiates;    Neonatal abstinence syndrome;   

DOI  :  10.1186/s13223-021-00617-3

来源: Springer

【 摘 要 】

Severe combined immunodeficiency (SCID) is a rare genetic condition characterized by significant T cell lymphopenia and impaired T cell function. Many jurisdictions use the quantitation of T cell receptor excision circles (TRECs) to screen for SCID in newborns, but false positives may be seen in several conditions. We report 3 newborns with neonatal abstinence syndrome who presented with decreased TREC copy number.

【 授权许可】

CC BY