Bone metastasis from noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP); a case report

BMC Endocrine Disorders

Hadis Mohammadzadeh Kosari¹  Seyed Rasoul Zakavi¹  Yasaman Fakhar¹  Atena Aghaee¹  Alireza Khooei²  Leonard Wartofsky³ 

[1] Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran;Pathology Department, Ghaem hospital, Mashhad University of Medical Sciences, Mashhad, Iran;Thyroid Cancer Research Unit, MedStar Health Research Institute, Georgetown University School of Medicine, Washington, DC, USA;

关键词: NIFTP;    Bone metastasis;    Thyroid cancer;    Thyroglobulin;    Case report;   

DOI  :  10.1186/s12902-021-00883-7

来源: Springer

【 摘 要 】

BackgroundThe term non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) was recently proposed as a non-malignant thyroid lesion with indolent behavior that does not require post-operative radio-iodine treatment. We are reporting a case of NIFTP with bone metastasis that is the second case reported so far.Case presentationWe describe a 38-year-old woman who presented with an indeterminate thyroid nodule and underwent total thyroidectomy with the finding of NIFTP on careful pathologic examination. However, her initial follow-up evaluation revealed a serum thyroglobulin level of > 300 ng/ml and a diagnostic whole body 131I scan demonstrated a focus of increased uptake in the left hemipelvis, confirmed on CT scan to be a lytic lesion in the left iliac bone. She was treated with 7.4GBq (200 mCi) of 131I and her follow-up 1 year later revealed an undetectable serum thyroglobulin and a negative whole body 131I scan with no visible uptake in the iliac bone indicating an excellent response.ConclusionThis case presentation reminds us to be alert to the rare occurrence of distant metastasis in NIFTP and the need for a case by case analysis and continuing post-operative follow-up for detection of residual or recurrent disease.

【 授权许可】

CC BY