Expression of mRNA vascular endothelial growth factor in hypospadias patients

BMC Urology

Ishandono Dachlan¹  Rahmadani P. Lestari²  Firly P. Fardilla²  Prahara Yuri² 

[1] Division of Plastic, Aesthetic and Reconstructive Surgery, Department of Surgery, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito Hospital, Yogyakarta, Indonesia;Division of Urology, Department of Surgery, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito Hospital, Jl. Kesehatan No.1, 55281, Yogyakarta, Indonesia;

关键词: Hypospadias;    VEGF;    Dartos tissue;    Elasticity;    Chordee;    Penile curvature;   

DOI  :  10.1186/s12894-021-00930-4

来源: Springer

【 摘 要 】

BackgroundHypospadias is a relatively common genital anomaly in humans, usually followed by inelastic dartos that causes penile chordee. Vascular endothelial growth factor (VEGF) is strongly linked to the viscoelasticity of tissues and their elastic phase. This study aimed to evaluate VEGF expressions in (1) fascia dartos between hypospadias and controls and (2) chordee severity.MethodsThis prospective cohort study involved 65 specimens from patients with hypospadias and ten specimens from controls. The samples were analyzed by quantitative real-time polymerase chain reaction (qPCR) for VEGF expression.ResultsThe expressions of VEGF were not different between proximal and distal hypospadias patients and controls (fold change: distal − 0.25; fold change: proximal − 0.2; p = 0.664). The scaled expressions related to chordee severity were mild − 0.1; moderate 0.1; severe − 0.25 (p = 0.660).ConclusionsVEGF expressions might not affect the severity of hypospadias and chordee, implying the pathogenesis is complex involving many growth factors. Further study with a larger sample size is necessary to clarify and confirm our findings.

【 授权许可】

CC BY