Associations between ADIPOQ rs2241766 SNP and breast cancer risk: a systematic review and a meta-analysis

Genes and environment

Wan Wang¹  Tong Sun¹  Xue Hu¹  Chunguo Cui¹ 

[1] Department of Breast Surgery, China-Japan Union Hospital of Jilin University, 126 Xiantai Blvd, 130033, Changchun, China;

关键词: Breast;    Cancer;    Genetics;    Meta-analysis;    Polymorphism;   

DOI  :  10.1186/s41021-021-00221-2

来源: Springer

【 摘 要 】

PurposeWe aimed to conduct a meta-analysis to accurately evaluate the potential association between ADIPOQ rs2241766 gene SNP and breast cancer risk.MethodsA systematic literature search on Cochrane Library, PubMed, Embase, Web of Science and China National Knowledge Infrastructure (CNKI) identified 8 articles with 1692 cases and 1890 controls. Strength of association was evaluated by pooled odds ratio (OR), 95 % confidence interval (CI) and p value. Funnel plots and Begger’s regression test were applied for testing the publication bias. Statistical analysis of all data was performed by Stata 12.0.ResultsThe meta-analysis results indicated that the ADIPOQ rs2241766 gene polymorphism did not significantly associated with the risk of breast cancer for these genetic models (TT vs. TG + GG: OR = 1.20, 95 % CI = 0.77–1.89, p=0.417; TT + TG vs. GG: OR = 1.05, 95 % CI = 0.71–1.56, p=0.805; T vs. G: OR =1.17, 95 % CI = 0.79–1.74, p=0.437).ConclusionsThis study indicated that no significant relationship between the ADIPOQ rs2241766 SNP and breast cancer. Further large-scale and well-designed studies will be indispensable to confirm our result.

【 授权许可】

CC BY