Global, regional, and national burden of Guillain–Barré syndrome and its underlying causes from 1990 to 2019

Journal of Neuroinflammation

Jianhong Wu¹  Haijiang Dai¹  Jude Dzevela Kong¹  Nicola Luigi Bragazzi¹  Haitham Jahrami²  Francesco Brigo³  Piergiorgio Lochner⁴  Andrea Naldi⁵  Sergio Garbarino⁶  Mark J. M. Sullman⁷  Paola Lanteri⁸  Saeid Safiri⁹  Mohammad-Reza Sohrabi^1,10  Ali-Asghar Kolahi^1,10  Seyed Aria Nejadghaderi^1,11 

[1]Centre for Disease Modelling, York University, Toronto, ON, Canada

[2]College of Medicine and Medical Sciences, Arabian Gulf University, Manama, Bahrain

[3]Department of Neurology, Franz Tappeiner Hospital, Merano, Italy

[4]Department of Neurology, Saarland University Medical Center, Homburg, Germany

[5]Department of Neuroscience “Rita Levi Montalcini”, University of Turin, Turin, Italy

[6]Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics and Maternal/Child Sciences (DINOGMI), Polyclinic Hospital San Martino IRCCS, University of Genoa, Genoa, Italy

[7]Department of Social Sciences, University of Nicosia, Nicosia, Cyprus

[8]Department of Life and Health Sciences, University of Nicosia, Nicosia, Cyprus

[9]Neurophysiology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy

[10]Neurosciences Research Center, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran

[11]Department of Community Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

[12]Social Determinants of Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

[13]Systematic Review and Meta-Analysis Expert Group (SRMEG), Universal Scientific Education and Research Network (USERN), Tehran, Iran

关键词: Global burden of disease;    Guillain–Barré syndrome;    Prevalence;    Years lived with disability;    Cause;   

DOI  :  10.1186/s12974-021-02319-4

来源: Springer

【 摘 要 】

BackgroundThis article presents the first detailed analysis of the prevalence and disability burden of Guillain–Barré syndrome (GBS) from 1990 to 2019 by cause, age, sex, and Socio-demographic Index (SDI) in 204 countries and territories.MethodsData from the Global Burden of Diseases Study (GBD) 2019 were used. GBD 2019 modelled the prevalence of GBS using hospital and claims data. Years lived with disability (YLDs) were estimated as the product of the GBS prevalence and the disability weight. This article also reported proportions in the age-standardised prevalence rate that were due to six underlying causes of GBS.ResultsIn 2019, there were 150,095 [95% uncertainty intervals (UI) 119,924 to 188,309] total cases of GBS worldwide, which resulted in 44,407 (95% UI 28,016 to 64,777) YLDs. Globally, there was a 6.4% (95% UI 3.6 to 9.5) increase in the age-standardised prevalence of GBS per 100,000 population between 1990 and 2019. High-income Asia Pacific [1.9 (95% UI: 1.5 to 2.4)] and East Asia [0.8 (95% UI: 0.6 to 1.0)] had the highest and lowest age-standardised prevalence rates (per 100,000), respectively, in 2019. Nationally, Japan [6.4 (95% UI: 5.3 to 7.7)] and China [0.8 (95% UI: 0.6 to 1.0)] had the highest and lowest age-standardised prevalence rates (per 100,000). The age-standardised burden of GBS increased with increasing age and was higher in males in all age groups. Furthermore, the age-standardised prevalence of GBS (per 100,000) had a positive association with the level of development, as measured by SDI, although this association was not strong. Upper respiratory infections and unknown causes accounted for the highest proportions of underlying causes.ConclusionsGlobally, the prevalence of GBS continues to increase. Geographical differences and strategies aimed at preventing infectious diseases should be considered in future health policy planning and decision-making processes. This study had several limitations, such as using the same disability weight for all causes and a reliance on hospital- and self-reported data, which should be addressed in future research.

【 授权许可】

CC BY