A multicentre, multi-national, double-blind, randomised, active-controlled, parallel-group clinical study to assess the safety and efficacy of PDA10 (Epoetin-alpha) vs. Eprex® in patients with anaemia of chronic renal failure

BMC Nephrology

Su Hyun Kim¹  Jae Hyun Chang²  Sung Gyun Kim³  Zaki Morad⁴  Ravindran Visvanathan⁵  Soo Kun Lim⁶  Chun Soo Lim⁷  Bak Leong Goh⁸  Jin Seok Jeon⁹ 

[1] Chung-Ang University Hospital, Seoul, South Korea;Gil Medical Centre, Gachon University College of Medicine, Incheon, South Korea;Hallym University Sacred Heart Hospital, Anyang, South Korea;KPJ Ampang Puteri Specialist Hospital, Ampang, Malaysia;Prince Court Medical Centre, Kuala Lumpur, Malaysia;Renal Division, Department of Medicine, Faculty of Medicine, University of Malaya, 59100, Kuala Lumpur, Malaysia;Seoul National University Boramae Medical Centre, Seoul, South Korea;Serdang Hospital, Kajang, Malaysia;Soonchunhyang University Hospital, Seoul, South Korea;

关键词: Anaemia;    Epoetin-α;    Haemodialysis;    PDA10;    Therapeutic equivalence;   

DOI  :  10.1186/s12882-021-02601-w

来源: Springer

【 摘 要 】

BackgroundErythropoietin stimulating agent (ESA) has been standard of care in treating renal anaemia for the past 20 years. Many patients have limited access to ESA in view of long-term costs leading to suboptimal ESA dosage. Biosimilar epoetin is a potential cost-effective alternative to originator for optimal renal anaemia management.ObjectiveTo determine efficacy and safety of PDA10 in treating renal anaemia in haemodialysis patients, in comparison to the originator epoetin-α, Eprex®.MethodsA phase 3, multicentre, multi-national, double-blind, randomised, active-controlled and parallel group study conducted over 40 weeks in Malaysia and Korea. End stage kidney disease patients undergoing regular haemodialysis who were on erythropoietin treatment were recruited. The study has 3 phases, which included a 12-week titration phase, followed by 28-week double-blind treatment phase and 24-week open-label extension phase.ResultsThe PDA10 and Eprex® were shown to be therapeutically equivalent (p < 0.0001) with mean absolute change in haemoglobin from baseline of − 0.176 (± 0.91) g/dl and − 0.118 (± 1.114) g/dl, respectively. Weekly dose change was 10.01 IU/kg/week in PDA10 group and 10.30 IU/kg/week in Eprex® group, which has no significant difference. There were no significant differences in the safety profile between PDA10 and Eprex® groups.ConclusionThis study has confirmed the therapeutic equivalence between PDA10 and Eprex® in terms of efficacy, dosage requirement and safety profile in haemodialysis patients with renal anaemia.Trial registrationThe study was registered with the National Medical Research Register (NMRR-13-400-16313). This study has been registered retrospectively with Clinical Research Information Service (CRiS), Republic of Korea on 25 March 2021.

【 授权许可】

CC BY