Shortened red blood cell age in patients with end-stage renal disease who were receiving haemodialysis: a cross-sectional study

BMC Nephrology

Toshika Okumiya¹  Ichiro Shiojima²  Sanae Kikuchi²  Tetsuro Sugiura²  Munemitsu Otagaki²  Yoshihiro Yamamoto²  Kenichi Fujii²  Nobuyuki Takahashi²  Koichiro Matsumura² 

[1] Department of Biomedical Laboratory Sciences, Faculty of Health Sciences, Kumamoto University, Kumamoto, Japan;Department of Medicine II, Kansai Medical University, 10-15 Fumizono-cho, 5708507, Moriguchi, Japan;

关键词: Anaemia;    Haemodialysis;    Peritoneal dialysis;    Red blood cell age;   

DOI  :  10.1186/s12882-020-02078-z

来源: Springer

【 摘 要 】

BackgroundThe causes of anaemia in patients with end-stage renal disease include a relative deficiency in erythropoietin production and complex clinical conditions. We aimed to investigate the underlying mechanisms of anaemia in patients with end-stage renal disease who were undergoing maintenance dialysis by measuring erythrocyte creatine levels.MethodsIn a cross-sectional study, we evaluated 69 patients with end-stage renal disease who were receiving haemodialysis (n = 55) or peritoneal dialysis (n = 14). Erythrocyte creatine level, a quantitative marker of mean red blood cell (RBC) age, was measured.ResultsThe mean RBC age was significantly shorter in the haemodialysis group than in the peritoneal dialysis group (47.7 days vs. 59.8 days, p < 0.0001), although the haemoglobin levels were comparable between the groups. A Spearman correlation coefficient analysis revealed that shortened RBC age positively correlated with transferrin saturation (r = 0.54), ferritin level (r = 0.47), and haptoglobin level (r = 0.39) but inversely related with reticulocyte (r = − 0.36), weekly doses of erythropoiesis-stimulating agents (ESAs; r = − 0.62), erythropoietin resistance index (r = − 0.64), and intradialytic ultrafiltration rate (r = − 0.32).ConclusionsShortened RBC age was observed in patients who were receiving maintenance haemodialysis and was associated with iron deficiency, greater haptoglobin consumption, higher ESA requirements, and poor erythropoietin responsiveness, as well as with greater intradialytic fluid extraction.

【 授权许可】

CC BY