The composition of lung microbiome in lung cancer: a systematic review and meta-analysis

BMC Microbiology

Sadegh Azimzadeh Jamalkandi¹  Fatemeh Abedini²  Parvin Shariati²  Mohammad Gholami Fesharaki³  Sadaf Najafi³  Ali Ahmadi⁴ 

[1] Chemical Injuries Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran;Department of Bioprocess Engineering, Institute of Industrial and Environmental Biotechnology, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran;Department of Biostatistics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran;Molecular Biology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran;

关键词: Lung microbiome;    Lung cancer;    Meta-analysis;    16S rRNA gene;    Metagenomics;   

DOI  :  10.1186/s12866-021-02375-z

来源: Springer

【 摘 要 】

BackgroundAlthough recent studies have indicated that imbalance in the respiratory microbiome composition is linked to several chronic respiratory diseases, the association between the lung microbiome and lung cancer has not been extensively studied. Conflicting reports of individual studies on respiratory microbiome alterations in lung cancer complicate the matter for specifying how the lung microbiome is linked to lung cancer. Consequently, as the first meta-analysis on this topic, we integrate publicly available 16S rRNA gene sequence data on lung tissue samples of lung cancer patients to identify bacterial taxa which differ consistently between case and control groups.ResultsThe findings of the current study suggest that the relative abundance of several bacterial taxa including Actinobacteria phylum, Corynebacteriaceae and Halomonadaceae families, and Corynebacterium, Lachnoanaerobaculum, and Halomonas genera is significantly decreased (p < 0.05) in lung tumor tissues of lung cancer patients in comparison with tumor-adjacent normal tissues.ConclusionsDespite the underlying need for scrutinizing the findings further, the present study lays the groundwork for future research and adds to our limited understanding of the key role of the lung microbiome and its complex interaction with lung cancer. More data on demographic factors and tumor tissue types would help establish a greater degree of accuracy in characterizing the lung microbial community which accords with subtypes and stages of the disease and fully capturing the changes of the lung microbiome in lung cancer.

【 授权许可】

CC BY