Impaired wakefulness and rapid eye movement sleep in dopamine-deficient mice

Molecular Brain

Masayo Fujita¹  Kazutaka Ikeda¹  Kazuto Kobayashi²  Kaeko Tanaka³  Mitsuaki Kashiwagi³  Mika Kanuka³  Chika Tatsuzawa³  Yu Hayashi⁴  Ayaka Nakai⁵ 

[1] Addictive Substance Project, Tokyo Metropolitan Institute of Medical Science, 156-8506, Setagaya-ku, Tokyo, Japan;Department of Molecular Genetics, Institute of Biomedical Sciences, Fukushima Medical University, 960-1295, Fukushima, Japan;International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 305-8575, Tsukuba, Japan;International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 305-8575, Tsukuba, Japan;Department of Human Health Sciences, Graduate School of Medicine, Kyoto University, 606-8507, Kyoto, Japan;International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 305-8575, Tsukuba, Japan;Doctoral Programs in Neuroscience, Degree Programs in Comprehensive Human Sciences, University of Tsukuba, 305-8575, Tsukuba, Japan;

关键词: Dopamine;    Mouse;    NREM sleep;    REM sleep;   

DOI  :  10.1186/s13041-021-00879-3

来源: Springer

【 摘 要 】

Despite the established roles of the dopaminergic system in promoting arousal, the effects of loss of dopamine on the patterns of sleep and wakefulness remain elusive. Here, we examined the sleep architecture of dopamine-deficient (DD) mice, which were previously developed by global knockout of tyrosine hydroxylase and its specific rescue in noradrenergic and adrenergic neurons. We found that DD mice have reduced time spent in wakefulness. Unexpectedly, DD mice also exhibited a marked reduction in the time spent in rapid eye movement (REM) sleep. The electroencephalogram power spectrum of all vigilance states in DD mice were also affected. These results support the current understanding of the critical roles of the dopaminergic system in maintaining wakefulness and also implicate its previously unknown effects on REM sleep.

【 授权许可】

CC BY