Combining prostate health index and multiparametric magnetic resonance imaging in estimating the histological diameter of prostate cancer

BMC Urology

Han Chang¹  Tzung-Ruei Li²  Chin-Chung Yeh²  Chao-Hsiang Chang²  Chi-Rei Yang²  Chi-Ping Huang³  Hsi-Chin Wu⁴  Po-Fan Hsieh⁵  Wen-Chin Huang⁶  Wei-Ching Lin⁷ 

[1] Department of Pathology, China Medical University Hospital, 40447, Taichung, Taiwan;Department of Urology, China Medical University Hospital, No. 2, Yu-Der Rd, 40447, Taichung, Taiwan;Department of Urology, China Medical University Hospital, No. 2, Yu-Der Rd, 40447, Taichung, Taiwan;School of Medicine, China Medical University, 40402, Taichung, Taiwan;Department of Urology, China Medical University Hospital, No. 2, Yu-Der Rd, 40447, Taichung, Taiwan;School of Medicine, China Medical University, 40402, Taichung, Taiwan;Department of Urology, China Medical University Beigang Hospital, 651012, Beigang, Yunlin, Taiwan;Department of Urology, China Medical University Hospital, No. 2, Yu-Der Rd, 40447, Taichung, Taiwan;School of Medicine, China Medical University, 40402, Taichung, Taiwan;Graduate Institute of Biomedical Sciences, School of Medicine, China Medical University, 40402, Taichung, Taiwan;Graduate Institute of Biomedical Sciences, School of Medicine, China Medical University, 40402, Taichung, Taiwan;School of Medicine, China Medical University, 40402, Taichung, Taiwan;Department of Radiology, China Medical University Hospital, 40447, Taichung, Taiwan;

关键词: Multiparametric magnetic resonance imaging;    Prostate cancer;    Prostate health index;    Tumor diameter;   

DOI  :  10.1186/s12894-021-00928-y

来源: Springer

【 摘 要 】

BackgroundAlthough multiparametric magnetic resonance imaging (mpMRI) is widely used to assess the volume of prostate cancer, it often underestimates the histological tumor boundary. The aim of this study was to evaluate the feasibility of combining prostate health index (PHI) and mpMRI to estimate the histological tumor diameter and determine the safety margin during treatment of prostate cancer.MethodsWe retrospectively enrolled 72 prostate cancer patients who underwent radical prostatectomy and had received PHI tests and mpMRI before surgery. We compared the discrepancy between histological and radiological tumor diameter stratified by Prostate Imaging-Reporting and Data System (PI-RADS) score, and then assessed the influence of PHI on the discrepancy between low PI-RADS (2 or 3) and high PI-RADS (4 or 5) groups.ResultsThe mean radiological and histological tumor diameters were 1.60 cm and 2.13 cm, respectively. The median discrepancy between radiological and histological tumor diameter of PI-RADS 4 or 5 lesions was significantly greater than that of PI-RADS 2 or 3 lesions (0.50 cm, IQR (0.00–0.90) vs. 0.00 cm, IQR (−0.10–0.20), p = 0.02). In the low PI-RADS group, the upper limit of the discrepancy was 0.2 cm; so the safety margin could be set at 0.1 cm. In the high PI-RADS group, the upper limits of the discrepancy were 1.2, 1.6, and 2.2 cm in men with PHI < 30, 30–60, and > 60; so the safety margin could be set at 0.6, 0.8, and 1.1 cm, respectively.ConclusionsRadiological tumor diameter on mpMRI often underestimated the histological tumor diameter, especially for PI-RADS 4 or 5 lesions. Combining mpMRI and PHI may help to better estimate the histological tumor diameter.

【 授权许可】

CC BY