Avoidance memory requires CaMKII activity to persist after recall

Molecular Brain

Gênedy Apolinário¹  Andressa Radiske¹  Lia R. M. Bevilaqua¹  João R. de Oliveira¹  Martín Cammarota¹  Janine I. Rossato²  Maria Carolina Gonzalez³ 

[1] Memory Research Laboratory, Brain Institute, Federal University of Rio Grande do Norte, Natal, Brazil;Memory Research Laboratory, Brain Institute, Federal University of Rio Grande do Norte, Natal, Brazil;Department of Physiology, Federal University of Rio Grande do Norte, Natal, Brazil;Memory Research Laboratory, Brain Institute, Federal University of Rio Grande do Norte, Natal, Brazil;Edmond and Lily Safra International Institute of Neuroscience, Macaíba, Brazil;

关键词: Reconsolidation;    PTSD;    Fear;    Hippocampus;    Retrieval;   

DOI  :  10.1186/s13041-021-00877-5

来源: Springer

【 摘 要 】

Avoidance memory is destabilized when recalled concurrently with conflicting information, and must undergo a hippocampus-dependent restabilization process called reconsolidation to persist. CaMKII is a serine/threonine protein kinase essential for memory processing; however, its possible involvement in avoidance memory reconsolidation has not yet been studied. Using pharmacological, electrophysiological and optogenetic tools, we found that in adult male Wistar rats hippocampal CaMKII is necessary to reconsolidate avoidance memory, but not to keep it stored while inactive, and that blocking reconsolidation via CaMKII inhibition erases learned avoidance responses.

【 授权许可】

CC BY