Development of a conceptual model for research on cyclical variation of patient reported outcome measurements (PROMs) in patients with chronic conditions: a scoping review

Journal of Patient-Reported Outcomes

A. J. Mewse¹  C. Green²  J. M. Valderas³  J. Coombes³  I. Porter³  A. F. Davey⁴ 

[1] Department of Psychology, College of Life and Environmental Sciences, University of Exeter, Exeter, UK;Health Economics Group, Institute of Health Research, University of Exeter Medical School, University of Exeter, Exeter, UK;Exeter Collaboration for Academic Primary Care (APEx), University of Exeter Medical School, University of Exeter, Exeter, UK;Health Services and Policy Research Group, Exeter Collaboration for Academic Primary Care, NIHR PenARC, University of Exeter Medical School, University of Exeter, Exeter, UK;Health Services and Policy Research Group, Exeter Collaboration for Academic Primary Care, NIHR PenARC, University of Exeter Medical School, University of Exeter, Exeter, UK;Exeter Collaboration for Academic Primary Care (APEx), University of Exeter Medical School, University of Exeter, Exeter, UK;

关键词: Patient reported outcome measurement;    Scoping review;    Variability;    Time-dependent;   

DOI  :  10.1186/s41687-021-00395-x

来源: Springer

【 摘 要 】

BackgroundAlthough circadian, seasonal, and other cycles have been observed for a number of chronic conditions, their impact on patient reported outcomes measurements (PROMs) has not been systematically explored, rendering our understanding of the effect of time of measurement on PROM scores very limited. The aim was to conduct a scoping review to determine what is known about how intra-individual cyclical variation might affect the way individuals with chronic conditions respond to patient-reported outcome measures.MethodsA protocol of a systematic scoping review was registered on PROSPERO (CRD42017058365). We developed a search strategy based on previous relevant reviews and implemented it in: MEDLINE, Embase, PsycINFO, and CINAHL. No restrictions were placed on article types and backward and forward citation searches were conducted. Screening and data extraction were independently completed by up to four reviewers. An adapted version of CASP criteria was used to appraise the quality of included articles. Concepts that were important in understanding the impact of cyclical variation on PROM scores were elicited from the papers and iteratively refined through discussion amongst the authors.Results2420 references resulted from the searches, with 33 articles meeting the inclusion criteria. Most study designs included observational research (particularly ecological momentary assessment), 2 were RCTs and 2 were systematic reviews. Studies mainly focused on specific health conditions: mental health, respiratory and musculoskeletal. There was a lack of qualitative research and theoretical framework to explore these concepts more fully. Five overarching concepts emerged: variation in outcomes, variation of scores, psychological status, individual factors, and environmental/situational factors. A conceptual model was developed outlining the relationships between these concepts.ConclusionsThere is empirical evidence that supports cyclical variation in PROM scores across different chronic conditions, with potential very significant implications for administration and interpretation of PROMs. The proposed conceptual model can support further research in this area.

【 授权许可】

CC BY