Eradication of Helicobacter pylori may improve dyspepsia in the elderly for the long term

BMC Gastroenterology

Sayoko Kinowaki¹  Masayoshi Ono¹  Naoya Sakamoto¹  Ikko Tanaka¹  Yoshihiko Shimoda¹  Masaki Inoue¹  Shoko Ono²  Mototsugu Kato³  Momoko Tsuda³  Keiko Yamamoto⁴  Yuichi Shimizu⁴ 

[1] Department of Gastroenterology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan;Department of Gastroenterology, Hokkaido University Hospital, Sapporo, Hokkaido, Japan;Department of Gastroenterology, National Hospital Organization Hakodate National Hospital, Hakodate, Hokkaido, Japan;Division of Endoscopy, Hokkaido University Hospital, Sapporo, Hokkaido, Japan;

关键词: Dyspepsia;    Helicobacter pylori;    Eradication therapy;    The elderly;   

DOI  :  10.1186/s12876-021-02027-6

来源: Springer

【 摘 要 】

BackgroundTherapy for eradication of Helicobacter pylori (H. pylori) improves symptoms of H. pylori-associated dyspepsia (HPD), but the effects of eradication in elderly patients are unclear. The aim of our study was to investigate dyspepsia symptoms and long-term effects of eradication in elderly patients.MethodsThis retrospective study included 496 patients who received H. pylori eradication therapy. The patients were divided into a group of elderly patients (group E: ≧ 65 years old) and a group of non-elderly patients (group N: < 65 years old). Abdominal symptoms were evaluated using a questionnaire about abdominal symptoms before eradication and after eradication (1–2 months and more than one year). Dyspepsia was defined as a score of 4 points or more for at least one of 4 items (postprandial fullness, early satiety, epigastric pain, and hunger pain). Improvement of symptoms was defined on the basis of changes in Global Overall Systems scores.ResultsThere were no differences in abdominal symptoms before eradication between the two groups. Successful eradication improved symptoms in patients with dyspepsia within 2 months (in 75.6% (56/74) of the patients in group N and in 64.5% (20/31) of the patients in group E). The questionnaire showed that 80% (32/40) of the patients in group N and 60% (12/20) of the patients in group E had long-term relief of dyspepsia. The scores for abdominal symptoms in group E continued to improve for a mean period of 54.8 months after eradication.ConclusionsEradication of H. pylori age-independently improved dyspepsia symptoms for the long term.

【 授权许可】

CC BY