Ambiguous definitions for baseline serum creatinine affect acute kidney diagnosis at the emergency department

BMC Nephrology

Wouter Tiel Groenestege¹  Imo Hoefer¹  Wouter van Solinge¹  Saskia Haitjema¹  Michael Niemantsverdriet²  Karin Kaasjager³  Jan Willem Uffen³  Romy Koopsen³  Ayman El Idrissi³  Meriem Khairoun⁴  Domenico Bellomo⁵ 

[1] Central Diagnostic Laboratory, University Medical Center Utrecht, Utrecht University, Room Number G03.551, UMC Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands;Central Diagnostic Laboratory, University Medical Center Utrecht, Utrecht University, Room Number G03.551, UMC Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands;SkylineDx, Lichtenauerlaan 40, 3062 ME, Rotterdam, The Netherlands;Department of Internal Medicine, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands;Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands;SkylineDx, Lichtenauerlaan 40, 3062 ME, Rotterdam, The Netherlands;

关键词: AKI;    Creatinine;    CKD-EPI;    Electronic health records;    Digital health;   

DOI  :  10.1186/s12882-021-02581-x

来源: Springer

【 摘 要 】

BackgroundAcute kidney injury (AKI) incidence is increasing, however AKI is often missed at the emergency department (ED). AKI diagnosis depends on changes in kidney function by comparing a serum creatinine (SCr) measurement to a baseline value. However, it remains unclear to what extent different baseline values may affect AKI diagnosis at ED.MethodsRoutine care data from ED visits between 2012 and 2019 were extracted from the Utrecht Patient Oriented Database. We evaluated baseline definitions with criteria from the RIFLE, AKIN and KDIGO guidelines. We evaluated four baseline SCr definitions (lowest, most recent, mean, median), as well as five different time windows (up to 365 days prior to ED visit) to select a baseline and compared this to the first measured SCr at ED. As an outcome, we assessed AKI prevalence at ED.ResultsWe included 47,373 ED visits with both SCr-ED and SCr-BL available. Of these, 46,100 visits had a SCr-BL from the − 365/− 7 days time window. Apart from the lowest value, AKI prevalence remained similar for the other definitions when varying the time window. The lowest value with the − 365/− 7 time window resulted in the highest prevalence (21.4%). Importantly, applying the guidelines with all criteria resulted in major differences in prevalence ranging from 5.9 to 24.0%.ConclusionsAKI prevalence varies with the use of different baseline definitions in ED patients. Clinicians, as well as researchers and developers of automatic diagnostic tools should take these considerations into account when aiming to diagnose AKI in clinical and research settings.

【 授权许可】

CC BY