The Role of Cell Organelles in Rheumatoid Arthritis with Focus on Exosomes

Biological Procedures Online

Abbas Pirpour Tazehkand¹  Armina Alagheband Bahrami²  Zahra Payandeh³  Faezeh Almasi⁴  Ali Azargoonjahromi⁵ 

[1] Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran;Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran;Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran;Pharmaceutical Biotechnology Lab, Department of Microbial Biotechnology, School of Biology and Center of Excellence in Phylogeny of Living Organisms, College of Science, University of Tehran, Tehran, Iran;Shiraz University of Medical Sciences, Shiraz, Iran;

关键词: Rheumatoid arthritis;    Exosome;    Autoimmune diseases;    Therapy;   

DOI  :  10.1186/s12575-021-00158-4

来源: Springer

【 摘 要 】

Auto-immune diseases involved at least 25% of the population in wealthy countries. Several factors including genetic, epigenetic, and environmental elements are implicated in development of Rheumatoid Arthritis as an autoimmune disease. Autoantibodies cause synovial inflammation and arthritis, if left untreated or being under continual external stimulation, could result in chronic inflammation, joint injury, and disability. T- and B-cells, signaling molecules, proinflammatory mediators, and synovium-specific targets are among the new therapeutic targets. Exosomes could be employed as therapeutic vectors in the treatment of autoimmune diseases. Herein, the role of cell organelle particularly exosomes in Rheumatoid Arthritis had discussed and some therapeutic applications of exosome highlighted.

【 授权许可】

CC BY