Prognosis and role of clinical and imaging features in patients with malignant pericardial effusion: a single-center study in China

BMC Cardiovascular Disorders

Shucai Wang¹  Ning Zhang¹  Chanchan Wang¹  Jiazheng Zhao² 

[1] Department of Cardiology, The Fourth Hospital of Hebei Medical University, 12 Health Road, 050011, Shijiazhuang, Hebei, People’s Republic of China;Department of Orthopedics, The Fourth Hospital of Hebei Medical University, 12 Health Road, 050011, Shijiazhuang, Hebei, People’s Republic of China;

关键词: Malignant pericardial effusion;    Clinical features;    Imaging performance;    Treatment;    Prognosis;   

DOI  :  10.1186/s12872-021-02331-9

来源: Springer

【 摘 要 】

BackgroundThe diagnosis of malignant pericardial effusion (MPE) is often associated with a poor prognosis, but due to the complexity and unspecific nature of MPE patients' clinical manifestations, imaging often performs an essential role in diagnosis and prognosis.MethodsPatients diagnosed with MPE between 2013 and 2018 at one tumor hospital were included and followed up. The data covered the basic clinical features, imaging findings, treatments and prognosis of patients with MPE, and the factors that may have affected the prognosis were explored.ResultsA total of 216 patients with MPE were included with the median age of 60 years. The most common primary cancer type was lung cancer (73.6%), the most common symptom was dyspnea (62.9%) and the most common abnormal electrocardiogram finding was sinus tachycardia (42.1%). The median survival time of the 216 patients with MPE was 13.7 months. The factors affecting prognosis were echocardiographic fluid signs (HR = 2.37, P = 0.010), electrocardiographic evidence of sinus tachycardia (HR = 1.76, P = 0.006) and echocardiographic evidence of cardiac tamponade (HR = 3.33, P < 0.001).ConclusionsMPE has complex clinical manifestations and an unsatisfactory prognosis. Echocardiographic fluid signs, electrocardiographic evidence of sinus tachycardia, and echocardiographic evidence of cardiac tamponade are independent risk factors affecting prognosis.

【 授权许可】

CC BY