Reactive oxygen species (ROS)-responsive nanoprobe for bioimaging and targeting therapy of osteoarthritis

Journal of Nanobiotechnology

Qiumei Lan¹  Wei Xiong¹  Yanting Zhan¹  Zhimin Li¹  Haimin Chen¹  Chong Shen²  Zainen Qin³  Ming Gao³  Li Zheng³  Jinmin Zhao⁴ 

[1] Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration, The First Affiliated Hospital of Guangxi Medical University, 530021, Nanning, China;Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration, The First Affiliated Hospital of Guangxi Medical University, 530021, Nanning, China;Department of Orthopedics, The Affiliated Hospital of Guilin Medical University, No. 15 Lequn Road, 541001, Guilin, Guangxi, China;Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration, The First Affiliated Hospital of Guangxi Medical University, 530021, Nanning, China;Guangxi Collaborative Innovation Center for Biomedicine, The First Affiliated Hospital of Guangxi Medical University, 530021, Nanning, China;Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration, The First Affiliated Hospital of Guangxi Medical University, 530021, Nanning, China;Guangxi Collaborative Innovation Center for Biomedicine, The First Affiliated Hospital of Guangxi Medical University, 530021, Nanning, China;Department of Orthopaedics Trauma and Hand Surgery, The First Affiliated Hospital of Guangxi Medical University, 530021, Nanning, China;Guangxi Key Laboratory of Regenerative Medicine, International Joint Laboratory On Regeneration of Bone and Soft Tissue, The First Affiliated Hospital of Guangxi Medical University, 530021, Nanning, China;

关键词: ROS-responsive;    Drug delivery;    Targeting therapy;    Osteoarthritis;   

DOI  :  10.1186/s12951-021-01136-4

来源: Springer

【 摘 要 】

Stimulus-responsive therapy that allows precise imaging-guided therapy is limited for osteoarthritis (OA) therapy due to the selection of proper physiological markers as stimulus. Based on that the over-production of Reactive Oxygen Species (ROS) is associated with the progression in OA, we selected ROS as markers and designed a cartilage targeting and ROS-responsive theranostic nanoprobe that can be used for effective bioimaging and therapy of OA. This nanoprobe was fabricated by using PEG micelles modified with ROS-sensitive thioketal linkers (TK) and cartilage-targeting peptide, termed TKCP, which was then encapsulated with Dexamethasone (DEX) to form TKCP@DEX nanoparticles. Results showed that the nanoprobe can smartly “turn on” in response to excessive ROS and “turn off” in the normal joint. By applying different doses of ROS inducer and ROS inhibitor, this nanoprobe can emit ROS-dependent fluorescence according to the degree of OA severity, helpful to precise disease classification in clinic. Specifically targeting cartilage, TKCP@DEX could effectively respond to ROS and sustained release DEX to remarkably reduce cartilage damage in the OA joints. This smart, sensitive and endogenously activated ROS-responsive nanoprobe is promising for OA theranostics.Graphical Abstract

【 授权许可】

CC BY