Blood cell-derived extracellular vesicles: diagnostic biomarkers and smart delivery systems

Bioengineered

Jiang Xia¹  Caining Wen²  Limei Xu³  Xiao Xu³  Li Duan⁴  Yujie Liang⁵  Peng Zhang⁶ 

[1] Department of Chemistry, and Center for Cell & Developmental Biology, School of Life Sciences, the Chinese University of Hong Kong, Shatin, Hong Kong SAR, Chin;Department of Orthopedics, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People’s Hospital, Shenzhen, Guangdong, Chin;Guangdong Provincial Research Center for Artificial Intelligence and Digital Orthopedic Technology, Shenzhen Second People’s Hospital, Shenzhen, Guangdong, Chin;Department of Orthopedics, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People’s Hospital, Shenzhen, Guangdong, Chin;Guangdong Provincial Research Center for Artificial Intelligence and Digital Orthopedic Technology, Shenzhen Second People’s Hospital, Shenzhen, Guangdong, Chin;Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, Chin;Department of Orthopedics, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People’s Hospital, Shenzhen, Guangdong, Chin;Guangdong Provincial Research Center for Artificial Intelligence and Digital Orthopedic Technology, Shenzhen Second People’s Hospital, Shenzhen, Guangdong, Chin;Shenzhen Institute of Geriatrics, Shenzhen, Guangdong Province, Chin;Department of Orthopedics, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People’s Hospital, Shenzhen, Guangdong, Chin;Shenzhen Kangning Hospital, Shenzhen Mental Health Center, Shenzhen, Guangdong, Chin;Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, Chin;

关键词: Blood cells;    extracellular vesicles;    biomarkers;    targeted delivery;   

DOI  :  10.1080/21655979.2021.1982320

来源: Taylor & Francis

【 摘 要 】

Extracellular vesicles (EVs) are released by most of the cells or tissues and act as nanocarriers to transfer nucleic acids, proteins, and lipids. The blood system is the most abundant source of extracellular vesicles for purification, and it has attracted considerable attention as a source of diagnostic biomarkers. Blood-derived extracellular vesicles, especially vesicles released from erythrocytes and platelets, are highly important in nanoplatform-based therapeutic interventions as potentially ideal drug delivery vehicles. We reviewed the latest research progress on the paracrine effects and biological functions of extracellular vesicles derived from erythrocytes, leukocytes, platelets, and plasma. From a clinical perspective, we summarize selected useful diagnostic biomarkers for therapeutic intervention and diagnosis. Especially, we describe and discuss the potential application of erythrocyte-derived extracellular vesicles as a new nano-delivery platform for the desired therapeutics. We suggest that blood-derived extracellular vesicles are an ideal nanoplatform for disease diagnosis and therapy.

【 授权许可】

CC BY