A new prognostic risk model based on autophagy-related genes in kidney renal clear cell carcinoma

Bioengineered

Zihao Ruan¹  Huayu Zhang²  Zicheng Wang³  Han Gao³  Peizhi Zhang⁴  Yingkun Xu⁴  Qinghua Xia⁵  Feng Chen⁶  Xiangyu Che⁶  Guangzhen Wu⁷ 

[1] Department of Nursing, Zhengzhou University, Zhengzhou, Chin;Department of Plastic and Reconstructive Surgery, Shandong Qianfoshan Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Chin;Department of Urology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Chin;Department of Urology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Chin;Department of Urology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Chin;Department of Urology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Chin;Department of Urology, The First Affiliated Hospital of Dalian Medical University, Dalian, Chin;Department of Urology, The First Affiliated Hospital of Dalian Medical University, Dalian, Chin;Department of Urology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Chin;

关键词: Autophagy;    kidney renal clear cell carcinoma;    tcga;    prognostic risk model;    nomogram;   

DOI  :  10.1080/21655979.2021.1976050

来源: Taylor & Francis

【 摘 要 】

This study aimed to explore the potential role of autophagy-related genes in kidney renal clear cell carcinoma (KIRC) and develop a new prognostic-related risk model. In our research, we used multiple bioinformatics methods to perform a pan-cancer analysis of the CNV, SNV, mRNA expression, and overall survival of autophagy-related genes, and displayed the results in the form of heat maps. We then performed cluster analysis and LASSO regression analysis on these autophagy-related genes in KIRC. In the cluster analysis, we successfully divided patients with KIRC into five clusters and found that there was a clear correlation between the classification and two clinicopathological features: tumor, and stage. In LASSO regression analysis, we used 13 genes to create a new prognostic-related risk model in KIRC. The model showed that the survival rate of patients with KIRC in the high-risk group was significantly lower than that in the low-risk group, and that there was a correlation between this grouping and the patients’ metastasis, tumor, stage, grade, and fustat. The results of the ROC curve suggested that this model has good prediction accuracy. The results of multivariate Cox analysis show that the risk score of this model can be used as an independent risk factor for patients with KIRC. In summary, we believe that this research provides valuable data supporting future clinical treatment and scientific research.

【 授权许可】

CC BY