Mitofusin 2, a key coordinator between mitochondrial dynamics and innate immunity

Virulence

Prashanta Silwal¹  In Soo Kim¹  Eun-Kyeong Jo¹ 

[1] Department of Microbiology, Chungnam National University College of Medicine, Daejeon, Kore;Infection Control Convergence Research Center, Chungnam National University College of Medicine, Daejeon, Kore;

关键词: Mitofusin-2;    mitochondrial dynamics;    innate immunity;    infections;   

DOI  :  10.1080/21505594.2021.1965829

来源: Taylor & Francis

【 摘 要 】

Remodeling of mitochondrial dynamics and mitochondrial morphology plays a pivotal role in the maintenance of mitochondrial homeostasis in response to pathogenic attacks or stress stimuli. In addition to their role in metabolism and energy production, mitochondria participate in diverse biological functions, including innate immune responses driven by macrophages in response to infections or inflammatory stimuli. Mitofusin-2 (MFN2), a mitochondria-shaping protein regulating mitochondrial fusion and fission, plays a crucial role in linking mitochondrial function and innate immune responses. In this article, we review the role of MFN2 in the regulation of innate immune responses during viral and bacterial infections. We also summarize the current knowledge on the role of MFN2 in coordinating inflammatory, atherogenic, and fibrotic responses. MFN2-mediated crosstalk between mitochondrial dynamics and innate immune responses may determine the outcomes of pathogenic infections.

【 授权许可】

CC BY