Integrative proteome analysis implicates aberrant RNA splicing in impaired developmental potential of aged mouse oocytes

Aging Cell

Wenjie Shu¹  Chao Ren¹  Yueshuai Guo²  Hao Zhang²  Yue Hu²  Qiqi Cao²  Yuanlin He²  Shuai Zhou²  Jie Huang²  Ran Huo²  Xuejiang Guo²  Congjing Wang²  Xue Bai²  Lu Liu²  Mingrui Li³ 

[1] Department of Biotechnology, Beijing Institute of Radiation Medicine, Beijing, China;State Key Laboratory of Reproductive Medicine, Department of Histology and Embryology, Suzhou Affiliated Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Nanjing, China;State Key Laboratory of Reproductive Medicine, Department of Histology and Embryology, Suzhou Affiliated Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Nanjing, China;Department of Clinical Nursing, School of Nursing, Nanjing Medical University, Nanjing, China;

关键词: Cdk9;    DNA damage;    oocyte aging;    oocyte quality;    preimplantation embryo;    proteomics;    PUF60;    splicing;   

DOI  :  10.1111/acel.13482

来源: Wiley

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