Advanced Maternal Age‐associated SIRT1 Deficiency Compromises Trophoblast Epithelial−Mesenchymal Transition through an Increase in Vimentin Acetylation

Aging Cell

Philip N. Baker¹  Chao Tong²  Huijia Fu²  Ping Xu²  Li Wen²  Hongbo Qi²  Sisi Li²  Jiaxiao Yu²  Yong Fu²  Liling Xiong²  Zhi Chen²  Xuan Ye²  Mark D. Kilby³  Richard Saffery⁴  Rufei Gao⁵ 

[1] College of Life Sciences, University of Leicester, Leicester, UK;Department of Obstetrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China;Ministry of Education‐International Collaborative Laboratory of Reproduction and Development, Chongqing, China;State Key Laboratory of Maternal and Fetal Medicine of Chongqing Municipality, Chongqing, China;Institute of Metabolism and System Research, University of Birmingham, Edgbaston, UK;Ministry of Education‐International Collaborative Laboratory of Reproduction and Development, Chongqing, China;Cancer, Disease and Developmental Epigenetics, Murdoch Children’s Research Institute, Parkville, Victoria, Australia;Ministry of Education‐International Collaborative Laboratory of Reproduction and Development, Chongqing, China;Laboratory of Reproductive Biology, School of Public Health and Management, Chongqing Medical University, Chongqing, China;

关键词: advanced maternal age;    epithelial−mesenchymal transition;    placenta;    senescence;    SIRT1;    trophoblast;   

DOI  :  10.1111/acel.13491

来源: Wiley

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