Identification of a small molecule SR9009 that activates NRF2 to counteract cellular senescence

Aging Cell

Li‐Bin Gao¹  Qing Jing¹  Zhi‐Hua Liu¹  Yu Sun¹  Peng Cai²  Ya‐Hong Wang³ 

[1] CAS Key Laboratory of Tissue Microenvironment and Tumor, Innovation Center for Intervention of Chronic Disease and Promotion of Health, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China;CAS Key Laboratory of Tissue Microenvironment and Tumor, Innovation Center for Intervention of Chronic Disease and Promotion of Health, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China;Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, China;Xiamen Key Laboratory of Physical Environment, Xiamen, China;Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, China;Xiamen Key Laboratory of Physical Environment, Xiamen, China;

关键词: cellular senescence;    DNA damage;    NRF2;    ROS;    SASP;    SR9009;   

DOI  :  10.1111/acel.13483

来源: Wiley

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