Journal of Nanobiotechnology | |
Understanding of catalytic ROS generation from defect-rich graphene quantum-dots for therapeutic effects in tumor microenvironment | |
Chuangang Hu1  Zi Gu1  Liming Dai1  Xichu Wang1  | |
[1] Australian Carbon Materials Centre (A-CMC), School of Chemical Engineering, University of New South Wales, 2052, Sydney, NSW, Australia; | |
关键词: Carbon-based metal-free catalyst; Graphene quantum dot; Defect; Reactive oxygen species; Tumor microenvironment; | |
DOI : 10.1186/s12951-021-01053-6 | |
来源: Springer | |
【 摘 要 】
Owing to their low cost, high catalytic efficiency and biocompatibility, carbon-based metal-free catalysts (C-MFCs) have attracted intense interest for various applications, ranging from energy through environmental to biomedical technologies. While considerable effort and progress have been made in mechanistic understanding of C-MFCs for non-biomedical applications, their catalytic mechanism for therapeutic effects has rarely been investigated. In this study, defect-rich graphene quantum dots (GQDs) were developed as C-MFCs for efficient ROS generation, specifically in the H2O2-rich tumor microenvironment to cause multi-level damages of subcellular components (even in nuclei). While a desirable anti-cancer performance was achieved, the catalytic performance was found to strongly depend on the defect density. It is for the first time that the defect-induced catalytic generation of ROS by C-MFCs in the tumor microenvironment was demonstrated and the associated catalytic mechanism was elucidated. This work opens a new avenue for the development of safe and efficient catalytic nanomedicine.
【 授权许可】
CC BY
【 预 览 】
Files | Size | Format | View |
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RO202110286383286ZK.pdf | 2783KB | download |