Association between serum alanine and aspartate aminotransferase and blood pressure: a cross-sectional study of Chinese freshmen

BMC Cardiovascular Disorders

Yan Chen¹  Lijun Zhu¹  Weiwei Chang¹  Mengyun Huang¹  Zhengmei Fang¹  Yuelong Jin¹  Yingshui Yao²  Lianping He³ 

[1] Department of Epidemiology and Biostatistics, School of Public Health, Wannan Medical College, No. 22, Wenchang Road, 241002, Wuhu, Anhui, China;Institute of Chronic Disease Prevention and Control, Wannan Medical College, No. 22, Wenchang Road, 241002, Wuhu, Anhui, China;Department of Epidemiology and Biostatistics, School of Public Health, Wannan Medical College, No. 22, Wenchang Road, 241002, Wuhu, Anhui, China;Institute of Chronic Disease Prevention and Control, Wannan Medical College, No. 22, Wenchang Road, 241002, Wuhu, Anhui, China;Department of Medicine, Anhui College of Traditional Chinese Medicine, No.18, Wuxia Shanxi Road, 241002, Wuhu, Anhui, China;School of Medicine, Taizhou University, 318000, Taizhou, China;

关键词: Alanine aminotransferase;    Aspartate aminotransferase;    Freshmen;    Hypertension;    Association;    Cross-sectional;   

DOI  :  10.1186/s12872-021-02282-1

来源: Springer

【 摘 要 】

BackgroundHigh blood pressure is a well-recognized risk factor for cardiovascular events, and the incidence of hypertension is increasing among young people. This study investigated the relationship between ALT and AST levels and hypertension among freshmen in China.MethodsThis cross-sectional study was conducted in the Anhui Province from September to November 2018. A total of 3114 freshmen underwent a physical examination including testing of biochemical indicators and a standardized questionnaire.ResultsThe overall prevalence of elevated ALT and AST were 6.8% and 2.3% among freshmen. The mean ALT and AST levels were higher in males (22.59 ± 21.98 vs.12.62 ± 10.30 U/L; 23.55 ± 12.24 vs. 20.02 ± 5.75 U/L, respectively). The prevalence of hypertension was significantly higher in men (16.1%) than in women (1.9%). The mean values of BMI, SBP, DBP, TC, TG, and LDL-C were found to be increased with elevated levels of serum ALT and AST in the quartiles (P for trend < 0.05). After adjusting for covariates, the risk of hypertension was significantly higher in the highest ALT quartile than in the lowest quartile (OR (95% CI) of 1.681 (1.028, 2.751) in males; 2.802 (1.102, 7.124) in females). A strong linear relationship was found between serum ALT levels and the odds of hypertension after adjustment for potential confounders only in total population and females (P for trend < 0.05).ConclusionsThese findings suggest that ALT level is significantly associated with hypertension both in male and female freshmen.

【 授权许可】

CC BY