Accuracy and precision of volumetric bone mineral density assessment using dual-source dual-energy versus quantitative CT: a phantom study

European Radiology Experimental

Stefan Wesarg¹  Giorgio Ascenti²  Tommaso D’Angelo²  Silvio Mazziotti²  Nils Große Hokamp³  Christoph Mader⁴  Katrin Eichler⁴  Iris Burck⁴  Renate M. Hammerstingl⁴  Tatjana Gruber-Rouh⁴  Jan Borggrefe⁵  Moritz H. Albrecht⁶  Vitali Koch⁶  Leona S. Alizadeh⁶  Simon S. Martin⁶  Leon D. Gruenewald⁶  Julian L. Wichmann⁶  Ibrahim Yel⁶  Lukas Lenga⁶  Christian Booz⁶  Thomas J. Vogl⁷  Nicole A. Huizinga⁸ 

[1] Cognitive Computing and Medical Imaging, Fraunhofer IGD, Darmstadt, Germany;Department of Biomedical Sciences and Morphological and Functional Imaging, University Hospital Messina, Messina, Italy;Department of Diagnostic and Interventional Radiology, University Hospital Cologne, Cologne, Germany;Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Frankfurt am Main, Germany;Department of Radiology, Neuroradiology and Nuclear Medicine, Minden Hospital, University of Kiel, Kiel, Germany;Division of Experimental Imaging, Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany;Division of Experimental Imaging, Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany;Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Frankfurt am Main, Germany;Interdisciplinary Center for Neuroscience, Goethe University of Frankfurt, Frankfurt am Main, Germany;

关键词: Bone density;    Dual-energy computed tomography;    Osteoporosis;    Phantoms (imaging);    Tomography (x-ray computed);   

DOI  :  10.1186/s41747-021-00241-1

来源: Springer

【 摘 要 】

BackgroundDual-source dual-energy computed tomography (DECT) offers the potential for opportunistic osteoporosis screening by enabling phantomless bone mineral density (BMD) quantification. This study sought to assess the accuracy and precision of volumetric BMD measurement using dual-source DECT in comparison to quantitative CT (QCT).MethodsA validated spine phantom consisting of three lumbar vertebra equivalents with 50 (L1), 100 (L2), and 200 mg/cm3 (L3) calcium hydroxyapatite (HA) concentrations was scanned employing third-generation dual-source DECT and QCT. While BMD assessment based on QCT required an additional standardised bone density calibration phantom, the DECT technique operated by using a dedicated postprocessing software based on material decomposition without requiring calibration phantoms. Accuracy and precision of both modalities were compared by calculating measurement errors. In addition, correlation and agreement analyses were performed using Pearson correlation, linear regression, and Bland-Altman plots.ResultsDECT-derived BMD values differed significantly from those obtained by QCT (p < 0.001) and were found to be closer to true HA concentrations. Relative measurement errors were significantly smaller for DECT in comparison to QCT (L1, 0.94% versus 9.68%; L2, 0.28% versus 5.74%; L3, 0.24% versus 3.67%, respectively). DECT demonstrated better BMD measurement repeatability compared to QCT (coefficient of variance < 4.29% for DECT, < 6.74% for QCT). Both methods correlated well to each other (r = 0.9993; 95% confidence interval 0.9984–0.9997; p < 0.001) and revealed substantial agreement in Bland-Altman plots.ConclusionsPhantomless dual-source DECT-based BMD assessment of lumbar vertebra equivalents using material decomposition showed higher diagnostic accuracy compared to QCT.

【 授权许可】

CC BY