Association between vitamin D receptor gene polymorphisms (Fok1 and Bsm1) and osteoporosis: a systematic review

Journal of Diabetes & Metabolic Disorders

Hamid Reza Barikani¹  Abbasali Keshtkar⁵  Reza Nezam Zadeh³  Mahboubeh Dini²  Patricia Khashayar⁵  Mahsa M Amoli⁴  Mehdi Ebrahimi⁵  Fateme Fayyazbakhsh⁵  Zahra Mohammadi³ 

[1] Dental Implant Research Center, Tehran University of Medical Sciences, Tehran, Iran;Non-communicable Disease Department, Iran Ministry of Health and Medical Education, Tehran, Iran;Department of biology, Damghan branch, Islamic Azad University, Damghan, Iran;EMRI, Dr Shariati Hospital, North Karegar St., Tehran 14114, Iran;Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

关键词: Bsm1;    Fok1;    Polymorphism;    Bone density;    Vitamin D receptor gene;    Osteoporosis;   

Others  :  1136060
DOI  :  10.1186/s40200-014-0098-x

 received in 2014-08-21, accepted in 2014-09-30,  发布年份 2014

【 摘 要 】

Osteoporosis is a health concern characterized by reduced bone mineral density (BMD) and increased risk of fragility fractures. Many studies have investigated the association between genetic variants and osteoporosis. Polymorphism and allelic variations in the vitamin D receptor gene (VDR) have been found to be associated with bone mineral density. However, many studies have not been able to find this association. Literature review was conducted in several databases, including MEDLINE/Pubmed, Scopus, EMBASE, Ebsco, Science Citation Index Expanded, Ovid, Google Scholar, Iran Medex, Magiran and Scientific Information Database (SID) for papers published between 2000 and 2013 describing the association between Fok1 and Bsm1 polymorphisms of the VDR gene and osteoporosis risk. The majority of the revealed papers were conducted on postmenopausal women. Also, more than 50% studies reported significant relation between Fok1, Bsm1 and osteoporosis. Larger and more rigorous analytical studies with consideration of gene-gene and gene-environment interactions are needed to further dissect the mechanisms by which VDR polymorphisms influence osteoporosis.

【 授权许可】

   
2014 Mohammadi et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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