Quality of life and treatment-related burden during ocular proton therapy: a prospective trial of 131 patients with uveal melanoma

Radiation Oncology

Aline-Isabel Riechardt¹  Antonia Joussen¹  Jens Heufelder¹  Ute Goerling²  Johannes Gollrad³  Christopher Rabsahl³  Volker Budach³  Dirk Boehmer³  Andrea Stroux⁴ 

[1] Department of Ophthalmology, Charité – Universitätsmedizin Berlin, Berlin, Germany;Department of Psycho-Oncology, CCCC, Charité – Universitätsmedizin Berlin, Berlin, Germany;Department of Radiation Oncology, Charité – Universitätsmedizin Berlin, Berlin, Germany;Institute of Biometry and Clinical Epidemiology, Charité – Universitätsmedizin Berlin, Berlin, Germany;

关键词: Uveal melanoma;    Proton therapy;    Quality of life;   

DOI  :  10.1186/s13014-021-01902-6

来源: Springer

【 摘 要 】

BackgroundProton beam therapy is a well-established treatment option for patients with uveal melanoma (UM). The treatment procedure, in general, includes placing radiopaque clips to ensure exact eye-positioning during radiotherapy, followed by the delivery of proton irradiation.The short-term burden associated with proton therapy in patients with UM has rarely been addressed. In this prospective study, we investigated the physiological and psychological aspects of proton therapy that might affect the well-being of patients during the different stages of treatment.MethodsDuring the treatment procedure, we conducted longitudinal assessments of the Quality of life (QOL), organ-specific symptoms, and psychological aspects in patients with UM with three questionnaires (EORTC QLQ-C30, EORTC QLQ-OPT30, and GAD-7). Patients completed questionnaires before clip surgery (T0), before proton therapy (T1), after completing treatment (T2), and three months after treatment completion (T3). We also collected data on tumor characteristics and socio-demographics to identify potential risk factors associated with high treatment burdens.ResultsWe prospectively included 131 consecutive patients. Questionnaire data showed a significant, temporary decline in global QOL and an increase in eye-related symptoms, as a result of the clip surgery (T0–T1). After treatment completion (T2), global QOL improved gradually, and none of the eye-related symptoms significantly deteriorated over the course of proton therapy. The global QOL returned to baseline levels three months after treatment (T3). We identified baseline anxiety as an independent risk factor for experiencing an acute treatment-related burden. Furthermore, we found interactions between GAD7 and patient sex showing that anxiety had a more pronounced effect on QOL outcome in female patients.ConclusionThe short-term treatment-related burden of ocular proton therapy appeared to be largely associated with the preceding clip surgery, rather than the irradiation procedure. We found that anxiety was strongly associated with experiencing QOL issues during the treatment procedure. Our findings could contribute to the development of future strategies for improving the treatment process and psycho-oncologic patient care.

【 授权许可】

CC BY