The quenching effect in PRESAGE? by a proton beam: Investigation of formulation dependence

9th International Conference on 3D Radiation Dosimetry

Carroll, M.^1,2 ; Alqathami, M.^1 ; Ibbott, G.^1

Department of Radiation Physics, University of Texas, MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston

TX

77030, United States^1

University of Texas at Houston Graduate, School of Biomedical Sciences, Houston

TX

77030, United States^2

关键词: Active components;    Chemical concentrations;    Linear energy transfer;    Proton therapy;    Quenching effect;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/847/1/012027/pdf
DOI  :  10.1088/1742-6596/847/1/012027

来源: IOP

【 摘 要 】

The radiochromic dosimeter PRESAGE® has shown potential in conventional radiotherapies, but it suffers from dose under-responding, or signal quenching, in proton therapy as a result of dependence on variations in the linear energy transfer (LET). Early investigations have shown the under-response is affected by the chemical concentration of the active components, but as yet this relationship has not been comprehensively measured. This study investigated the impact of PRESAGE® formulation changes on signal quenching to determine the magnitude by which the quenching can be minimized.