Evaluation of the anti-inflammatory activities of solvent fractions of Commelina ascendens

Journal of Modern Methods in Numerical Mathematics

article

Chukwuemeka S. Nworu¹  Ikechukwu E. Peter¹  Akachukwu M. Onwuka¹ 

[1] Department of Pharmacology & Toxicology, Faculty of Pharmaceutical Sciences, University of Nigeria

关键词: Commelina ascendens;    egg albumin;    cotton pellet;    inflammation;   

DOI  :  10.20454/jeaas.2021.1652

学科分类：社会科学、人文和艺术（综合）

来源: Modern Science Publishers

【 摘 要 】

To evaluate the anti-inflammatory properties of the fractions of Commelina ascendens in rats. Egg albumin induced paw oedema and cotton pellet induced granuloma in rats were used to determine the anti-inflammatory activities of n-hexane (HF), ethylacetate (EF) and butanol (BF) fractions of Commelina ascendens. BF (200 mg/kg) significantly inhibited (p<0.05) oedema induced by egg albumin by producing 3.22 % protection at 4 h post-treatment. EF, HF and BF significantly (p<0.05) decreased the granuloma tissue caused by cotton pellet. The phytochemical screening of HF, EF and BF revealed the presence of saponin, tannins, flavonoids, steroids, carbohydrates. The extract did not show any sign of toxicity up to 5000 mg/kg body weight of mice. The results obtained justified the use of this plant in traditional medicine for the treatment of inflammation and may provide a basis for the development of anti-inflammatory agents.

【 授权许可】

Unknown