Temporal change in Syndecan-1 as a therapeutic target and a biomarker for the severity classification of COVID-19

Thrombosis Journal

Kazuya Sakai¹  Yasufumi Oi¹  Mototsugu Nishii¹  Masayuki Iwashita¹  Fumihiro Ogawa¹  Tomoki Nakagawa¹  Takao Miyagawa¹  Ichiro Takeuchi¹  Hayato Taniguchi¹  Kento Nakajima¹  Ryo Saji¹  Takeru Abe¹  Reo Matsumura¹  Kohei Takahashi¹ 

[1] Department of Emergency Medicine, Yokohama City University, School of Medicine, 3-9 Fukuura, Kanazawa-ku, 236-0004, Yokohama, Kanagawa, Japan;

关键词: COVID-19;    Syndecan-1;    Endothelial injury;    Glycocalyx;    Severity;    Classification;   

DOI  :  10.1186/s12959-021-00308-4

来源: Springer

【 摘 要 】

BackgroundCoronavirus disease 2019 (COVID-19) pneumonitis associated with severe respiratory failure is associated with high mortality. The pathogenesis of COVID-19 is associated with microembolism or microvascular endothelial injuries. Here, we report that syndecan-1 (SDC-1), a component of the endothelial glycocalyx, may be a biomarker of severity classification for COVID-19 related to endothelial injury.Methods and analysisWe analyzed the data of COVID-19 patients for 1 year from February 2020 at Yokohama City University Hospital and Yokohama City University Medical Center Hospital. We selected COVID-19 patients who required admission care, including intensive care, and analyzed the classification of severe and critical COVID-19 retrospectively, using various clinical data and laboratory data with SDC-1 by ELISA.ResultsWe analyzed clinical and laboratory data with SDC-1 in five severe COVID-19 and ten critical COVID-19 patients. In the two groups, their backgrounds were almost the same. In laboratory data, the LDH, CHE, and CRP levels showed significant differences in each group (P = 0.032, P < 0.0001, and P = 0.007, respectively) with no significant differences in coagulation-related factors (platelet, PT-INR, d-dimer, ISTH score; P = 0.200, 0.277, 0.655, and 0.36, respectively). For the clinical data, the SOFA score was significantly different from admission day to day 14 of admission (p < 0.0001). The SDC-1 levels of critical COVID-19 patients were significantly higher on admission day and all-time course compared with the levels of severe COVID-19 patients (P = 0.009 and P < 0.0001, respectively).ConclusionsTemporal change of SDC-1 levels closely reflect the severity of COVID-19, therefore, SDC-1 may be a therapeutic target and a biomarker for the severity classification of Covid-19.

【 授权许可】

CC BY